期刊
INTERNATIONAL JOURNAL OF PEDIATRIC OBESITY
卷 5, 期 2, 页码 157-160出版社
INFORMA HEALTHCARE
DOI: 10.3109/17477160903111789
关键词
-
类别
资金
- Obetech Obesity Research Center, Richmond
- LG Life Science to the Department of Pediatrics at the National Police Hospital, Seoul, Korea
- Health Promotion Team to the Department of Pediatrics of the National Medical Center, Seoul, Korea
Background. Human adenovirus-36 (Ad-36) is thought to induce obesity by a direct effect of the viral E4orf1 gene on lipogenic enzymes in host adipocytes. Ad-36 prevalence is 30% in obese adults, but prevalence has not been reported in childhood obesity. Objectives. To determine the prevalence of Ad-36 infection in obese Korean children (age 14.8 +/- 1.9; range 8.3-6.3 years); correlation of infection with BMI z-score and other obesity measures. Methods. Blood was drawn at the annual school physical exam or clinic visit; Ad-36 status was determined by serum neutralization assay; and routine serum chemistry values. Results. A total of 30% of subjects were positive (N = 25) for Ad-36; 70% were negative (N = 59). Significantly higher BMI z-scores (1.92 vs. 1.65, p < 0.01) and waist circumferences (96.3 vs. 90.7 cm, p = 0.05) were found in infected versus uninfected children. Cardiovascular risk factors were not significantly different. Conclusions. Ad-36 infection is common in obese Korean children and correlates highly with obesity. Ad-36 may have played a role in the obesity and Type 2 diabetes epidemic in children.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据