期刊
MOLECULAR & CELLULAR PROTEOMICS
卷 15, 期 2, 页码 368-381出版社
ELSEVIER
DOI: 10.1074/mcp.R115.051482
关键词
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资金
- Alexander-von-Humboldt Foundation (AvH)
- Bundesministerium fur Forschung und Technologie (BMBF)
- Deutscher Akademischer Austauschdienst (DAAD)
- Deutsche Forschungsgemeinschaft (DFG)
- Leibniz Foundation (Pakt fur Forschung)
- EU-FP7 MC-ITN NPlast
- CBBS
- Schram Foundation
The advances in mass spectrometry based proteomics in the past 15 years have contributed to a deeper appreciation of protein networks and the composition of functional synaptic protein complexes. However, research on protein dynamics underlying core mechanisms of synaptic plasticity in brain lag far behind. In this review, we provide a synopsis on proteomic research addressing various aspects of synaptic function. We discuss the major topics in the study of protein dynamics of the chemical synapse and the limitations of current methodology. We highlight recent developments and the future importance of multidimensional proteomics and metabolic labeling. Finally, emphasis is given on the conceptual framework of modern proteomics and its current shortcomings in the quest to gain a deeper understanding of synaptic plasticity.
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