期刊
INTERNATIONAL JOURNAL OF ONCOLOGY
卷 44, 期 5, 页码 1607-1613出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2014.2327
关键词
decursin; MMP-9; invasion; PKC alpha; NF-kappa B; MCF-7
类别
资金
- National Research Foundation of Korea (NRF) - Korea government (MEST) [2011-0030130]
- Chonbuk National University Hospital Research Institute of Clinical Medicine
Decursin, a coumarin compound, was first isolated from the roots of Angelica gigas almost four decades ago. It was found to exhibit cytotoxicity against various human cancer cells and to possess anti-amnesic activity in vivo through the inhibition of AChE activity. However, the effect of decursin on breast cancer invasion is unknown. Matrix metalloproteinase-9 (MMP-9) is known to be an important factor for cancer cell invasion. Therefore, in this study, we investigated the inhibitory effect of decursin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion, as well as the molecular mechanisms involved in MCF-7 cells. Our results showed that decursin inhibits TPA-induced MMP-9 expression and cell invasion through the suppression of NF-kappa B. Furthermore, decursin repressed the TPA-induced phosphorylation of p38 MAPK and inhibited TPA-induced translocation of PKC alpha from the cytosol to the membrane, but did not affect the translocation of PKC delta. These results indicate that decursin-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of the PKC alpha, MAPK and NF-kappa B pathways in MCF-7 cells. Thus, decursin may have potential value in restricting breast cancer metastasis.
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