期刊
INTERNATIONAL JOURNAL OF ONCOLOGY
卷 44, 期 3, 页码 912-917出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2013.2238
关键词
extracellular matrix metalloproteinase inducer; epidermal growth factor receptor; head and neck cancer; matrix metalloproteinase; invasion; migration; proliferation
类别
资金
- JSPS KAKENHI [24791740]
- Grants-in-Aid for Scientific Research [24791740] Funding Source: KAKEN
It has been reported that the epidermal growth factor receptor (EGFR) expression is associated with the extracellular matrix metalloproteinase inducer (EMMPRIN) in some solid tumors; however, the relationship of EMMPRIN with EGFR in head and neck cancers is not fully understood. To determine the relationship between EMMPRIN and EGFR in head and neck squamous cell carcinoma (HNSCC), HNSCC cells were stimulated with epidermal growth factor (EGF), a ligand of EGFR. EMMPRIN expression in HNSCC cells was upregulated by EGF. In addition, EGF stimulation induced HNSCC cell invasion and MMP-9 expression. This increase in invasion and MMP-9 expression was abrogated by downmodulation of EMMPRIN. Furthermore, to determine the effects of combined EMMPRIN and EGFR targeting in HNSCC, HNSCC cells were treated with an EMMPRIN function-blocking antibody and the EGFR inhibitor AG1478. This combined treatment resulted in greater inhibition of HNSCC cell proliferation and migration compared with the individual agents alone. These results suggest that EMMPRIN mediates EGFR-induced tumorigenicity and that combined targeting of EMMPRIN and EGFR may be an efficacious treatment approach.
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