期刊
INTERNATIONAL JOURNAL OF ONCOLOGY
卷 39, 期 4, 页码 973-980出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2011.1086
关键词
icariin; Leydig cell tumor; apoptosis; piwil4
类别
资金
- National Nature Science Foundation of China [30772346, 30300422, 30901062]
- Educational Commission of Chongqing, China [KJ070320]
The Leydig cell tumor, derived from interstitial cells, is a rare neoplasm. In most cases, Leydig cell tumors are benign, however, if the tumor is malignant, no effective treatments are currently available. In this study, we aimed to evaluate the effects of icariin on the growth of the mouse Leydig tumor cell line MLTC-1 and to examine its underlying mechanism. Icariin caused a dose-dependent decrease in the viability of MLTC-1 cells, which coincided with an increase in cell apoptosis through regulation of the expression of Bcl-2/Bax and cytochrome c, activation of caspase-9 and -3. Moreover, the pro-apoptotic effect of icariin on MLTC-1 cells is related to piwil4, since icariin induced a decrease in piwil4 protein expression and piwil4 silencing significantly enhanced the cytotoxic effects of icariin in MLIC-1 cells. These findings suggest a novel anticancer effect of icariin in Leydig cell tumor through activation of the mitochondrial pathway and down-regulation of the expression of piwil4.
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