期刊
INTERNATIONAL JOURNAL OF ONCOLOGY
卷 40, 期 4, 页码 1089-1096出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2011.1276
关键词
realgar; acute promyelocytic leukemia; apoptosis; differentiation; oligonucleotide microarray
类别
资金
- National Natural Science Foundation of China [30300139, 30801062, 30900548]
- Shanghai Municipal Commission for Education [07zz43]
- Natural Science Foundation of Shanghai Municipal Commission for Science and Technology [11ZR1423400]
- Postdoctoral Science Foundation of Shanghai Municipal Commission for Science and Technology
Realgar has been used in Western medicine and Chinese traditional medicine since ancient times, and its promising anticancer activity has attracted much attention in recent years, especially for acute promyelocytic leukemia (APL). However, the therapeutic action of realgar treatment for APL remains to be fully elucidated. Cellular cytotoxicity, proliferation, apoptosis and differentiation were comprehensively investigated in realgar-treated cell lines derived from PML-RAR alpha+ APL patient, including the all-trans retinoic acid (ATRA)-sensitive NB4 and ATRA-resistant MR2 cell lines. For analysis of key regulators of apoptosis and differentiation, gene expression profiles were performed in NB4 cells. Realgar was found to induce apoptosis and differentiation in both cell lines, and these effects were exerted simultaneously. Gene expression profiles indicated that genes influenced by realgar treatment were involved in the modulation of signal transduction, translation, transcription, metabolism and the immune response. Given its low toxicity, realgar is a promising alternative reagent for the therapy of APL. Our data contribute to an understanding of the underlying mechanism responsible for the therapeutic effects of realgar in the clinical treatment of APL.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据