期刊
INTERNATIONAL JOURNAL OF ONCOLOGY
卷 34, 期 3, 页码 673-680出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo_00000193
关键词
oral squamous cell carcinoma; lymph node metastasis; VEGF-C; VEGF-D; lymphatic vessel density
类别
资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
The prognosis of patients with oral squamous cell carcinoma (SCC) is influenced by the presence of lymph node metastasis. In this study, we analyzed the relationship between lymphangiogenesis and the expression of VEGF-C and VEGF-D in association with lymph node metastasis in oral SCC. Oral SCC biopsy specimens (160 cases) were examined for lymphatic vessel density (LVD) and the expression of VEGF-C and VEGF-D immunohistochemically. The levels of VEGF-C and VEGF-D expression and LVD were significantly associated with lymph node metastasis (p < 0.001). The expression of VEGF-C and VEGF-D increased the LVD significantly (p < 0.001). Multivariate analysis showed that VEGF-C expression and LVD were significantly associated with lymph node metastasis (p < 0.001). This study presents clinical evidence for the important roles of VEGF-C and VEGF-D in lymphangiogenesis and lymphatic metastasis of oral SCC, and suggests that VEGF-C or LVD can effectively predict lymphatic metastasis of oral SCC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据