期刊
INTERNATIONAL JOURNAL OF OBESITY
卷 38, 期 1, 页码 120-125出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ijo.2013.56
关键词
fat distribution; gene expression; waist-hip ratio; GWAS
资金
- DFG (Deutsche Forschungsgemeinschaft [KO 3880/1-2, KL 2346, SFB-1052]
- German Diabetes Association (DDG)
- LIFE (Leipzig Research Center for Civilization Diseases, Universitat Leipzig
- National Institute for Health Research [NF-SI-0611-10099] Funding Source: researchfish
OBJECTIVE: We hypothesized that genes within recently identified loci associated with waist-hip ratio (WHR) exhibit fat depot-specific mRNA expression, which correlates with obesity-related traits. METHODS: Adipose tissue (AT) mRNA expression of 6 genes (TBX15/WARS2, STAB1, PIGC, ZNRF3 and GRB14) within these loci showing coincident cis-expression quantitative trait loci was measured in 222 paired samples of human visceral (vis) and subcutaneous (sc) AT. The relationship of mRNA expression levels with obesity-related quantitative traits was assessed by Pearson's correlation analyses. Multivariate linear relationships were assessed by generalized linear regression models. RESULTS: Whereas only PIGC, ZNFR3 and STAB1 mRNA expression in sc AT correlated nominally with WHR (P < 0.05, adjusted for age and sex), mRNA expression of all studied genes in at least one of the fat depots correlated significantly with vis and/or sc fat area (P ranging from 0.05 to 4.0 x 10(6), adjusted for age and sex). Consistently, the transcript levels of WARS, PIGC and GRB14 were nominally associated with body mass index (BMI) (P ranging from 0.02 to 9.2 x 10(5), adjusted for age and sex). Moreover, independent of sex, obesity and diabetes status, differential expression between vis and sc AT was observed for all tested genes (P < 0.01). Finally, the rs10195252 T-allele was nominally associated with increased GRB14 sc mRNA expression (P = 0.025 after adjusting for age, sex and BMI). CONCLUSIONS: Our data including the inter-depot variability of mRNA expression suggests that genes within the WHR-associated loci might be involved in the regulation of fat distribution.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据