期刊
INTERNATIONAL JOURNAL OF OBESITY
卷 37, 期 12, 页码 1603-1607出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ijo.2013.48
关键词
bariatric surgery; vagus nerve; Roux-en-Y gastric bypass; mouse; diabetes
资金
- NIDDK NIH HHS [K08 DK091511] Funding Source: Medline
This study investigated the anatomical integrity of the vagal innervation to the gastrointestinal tract following Roux-en-Y gastric bypass (RYGB) in the mouse. Specifically, the surgical procedure was performed in high-fat-fed reporter mice (Phox2b-Cre-tdTomato), in which the entire vagal innervation of the gastrointestinal tract was fluorescently labeled. As a result, our anatomical observations revealed both qualitative and quantitative changes of the vagal supply to the gut after RYGB. This included the extensive denervation of the glandular and distal stomach, and sites of surgical interventions (clipping and anastomosis). Furthermore, the stomach wall after RYGB frequently contained dystrophic axons and endings, suggestive of vagal neurodegeneration. In contrast, RYGB did not significantly modify the innervation to the rest of the intestines and glucostatic organs. In summary, the present study describes a previously unrecognized pattern of vagal remodeling and denervation following RYGB. Our findings may serve as a guideline for future investigations on the role of gut-brain communication in bariatric surgery.
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