期刊
INTERNATIONAL JOURNAL OF OBESITY
卷 35, 期 12, 页码 1455-1465出版社
SPRINGERNATURE
DOI: 10.1038/ijo.2011.56
关键词
leptin; insulin; inflammation; nutrient; innate immunity; hypothalamus
资金
- NIDDK NIH HHS [R01 DK083042, R01 DK090320] Funding Source: Medline
Energy homeostasis involves a complex network of hypothalamic and extra-hypothalamic neurons that transduce hormonal, nutrient and neuronal signals into responses that ultimately match caloric intake to energy expenditure and thereby promote stability of body fat stores. Growing evidence suggests that rather than reflecting a failure to regulate caloric intake, common forms of obesity involve fundamental changes to this homeostatic system that favor the defense of an elevated level of body adiposity. This article reviews emerging evidence that during high-fat feeding, obesity pathogenesis involves fundamental alteration of hypothalamic systems that regulate food intake and energy expenditure. International Journal of Obesity (2011) 35, 1455-1465; doi:10.1038/ijo.2011.56; published online 8 March 2011
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