期刊
INTERNATIONAL JOURNAL OF OBESITY
卷 34, 期 6, 页码 1051-1059出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ijo.2010.20
关键词
liver disease; overweight; prospective cohort studies; Scotland
资金
- Chief Scientist Office of the Scottish Government [CZG/2/421]
- UK Medical Research Council
- Chief Scientist Office at the Scottish Government Health Directorates
- MRC [MC_U130059821, G0600705] Funding Source: UKRI
- Chief Scientist Office [CZG/2/421] Funding Source: researchfish
- Medical Research Council [MC_U130059821, G0600705] Funding Source: researchfish
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0755225] Funding Source: National Science Foundation
Objectives: To analyse the relationship between body mass index (BMI) and liver disease in men and women. Design: The Midspan prospective cohort studies. Participants: The three studies were: Main study, screened in 1965-1968, workplaces across Scotland, the general population of the island of Tiree and mainland relatives; Collaborative study, conducted from 1970 to 1973, 27 workplaces in Glasgow, Clydebank and Grangemouth; Renfrew/Paisley general population study, screened in 1972-1976. After exclusions there were 16 522 men and 10 216 women, grouped by BMI into under/normal weight (< 25 kg m(-2)), overweight (25 to < 30 kg m(-2)) and obese (>= 30 kg m(-2)). Measurements: Relative rates (RRs) of liver disease mortality, subdivided into liver cancer and all other liver disease, by BMI category and per s.d. increase in BMI, followed-up to end 2007. RRs of liver disease from any diagnosis on the death certificate, hospital discharge records or cancer registrations (Collaborative and Renfrew/Paisley studies only 13 027 men and 9328 women). Analyses adjusted for age and study, then other confounders. Results: In total, 146 men (0.9%) and 61 women (0.6%) died of liver disease as main cause. There were strong associations of BMI with liver disease mortality in men (RR per s.d. increase in BMI 1.41 (95% confidence interval 1.21-1.65)). Obese men had more than three times the rate of liver disease mortality than under/normal weight men. Adjustment for other risk factors had very little effect. No substantial or robust associations were observed in women. In all, 325 men (2.5%) and 155 women (1.7%) had liver disease established from any source. Similar positive associations were observed for men, and there was evidence of a relationship in women. Conclusions: BMI is related to liver disease, although not to liver disease mortality in women. The current rise in overweight and obesity may lead to a continuing epidemic of liver disease. International Journal of Obesity (2010) 34, 1051-1059; doi:10.1038/ijo.2010.20; published online 9 February 2010
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