期刊
INTERNATIONAL JOURNAL OF OBESITY
卷 34, 期 -, 页码 S17-S22出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ijo.2010.178
关键词
thermogenesis; brown adipose; UCP1; PRDM16
资金
- NIH [DK081605, DK 19525]
- DERC at the University of Pennsylvania
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R00DK081605, P30DK019525, K99DK081605] Funding Source: NIH RePORTER
Brown adipose tissue (BAT) is a specialized endothermic tissue in eutherian mammals that protects against hypothermia. Heat production by BAT may also be stimulated by overfeeding as an apparent counter regulatory mechanism to prevent excessive adipose accumulation. Genetic studies in rodents have overwhelmingly demonstrated an antiobesity effect for BAT. There is thus substantial biomedical interest in developing methods to increase the amount or function of BAT as a means to combat obesity. Furthermore, the recent discovery that adult humans have rather significant amounts of active BAT raises speculation that this tissue may naturally affect body weight in humans. Recent advances in our understanding of the transcriptional regulation of brown adipocyte development and adaptive thermogenesis are reviewed here. International Journal of Obesity (2010) 34, S17-S22; doi:10.1038/ijo.2010.178
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