期刊
INTERNATIONAL JOURNAL OF OBESITY
卷 34, 期 1, 页码 203-206出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ijo.2009.208
关键词
leptin; vascular compliance; aorta; pulse wave velocity
资金
- NIH/NHLBI [R01-HL077785, R01-AG021523, K08-HL076220]
- WW Smith Charitable Trust
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [K08HL076220, R01HL077785] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG021523] Funding Source: NIH RePORTER
The adipocytokine leptin centrally regulates body weight by enhancing metabolic rate and signaling satiety, but it also has wide-ranging peripheral effects. Leptin receptors are expressed on vascular smooth muscle cells and have a role in maintaining vascular tone. We investigated the vascular effects of leptin repletion or calorie restriction on leptin-deficient mice (ob/ob) and a leptin antagonist on wild-type (WT) mice. Aortic compliance was assessed by the measurement of pulse wave velocity by noninvasive Doppler; blood pressure was measured by left ventricular catheterization. We found that ob/ob mice have much stiffer aortas than WT mice and that reduction in aortic stiffness was greater in ob/ob mice treated with leptin vs calorie restriction, despite similar weight loss. Interestingly, treating WT mice with a leptin antagonist increases aortic stiffness with no change in weight. Thus, we conclude that leptin is essential for maintaining normal aortic compliance independent of body weight. International Journal of Obesity (2010) 34, 203-206; doi:10.1038/ijo.2009.208; published online 6 October 2009
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据