4.5 Article

Weight change and all-cause, cancer and cardiovascular disease mortality in Japanese men and women: the Japan Public Health Center-Based Prospective Study

期刊

INTERNATIONAL JOURNAL OF OBESITY
卷 34, 期 2, 页码 348-356

出版社

NATURE PUBLISHING GROUP
DOI: 10.1038/ijo.2009.234

关键词

cancer; cardiovascular diseases; cohort studies; Japan; mortality; weight change

资金

  1. Grants-in-Aid for Cancer Research [19shi-2]
  2. Ministry of Health, Labour and Welfare of Japan [H19-016]

向作者/读者索取更多资源

Background: It is unclear whether weight change during adulthood influences subsequent mortality in Asian populations, who have a relatively lean body mass. Objective: To assess the relation of weight change over 5 years to all-cause, cancer and cardiovascular disease mortality among Japanese men and women. Design: Subjects were 36 220 men and 44 091 women aged between 45 and 75 years without a history of serious disease at baseline. Weight change was calculated as the difference of body weight between two surveys with a 5-year interval. Results: During 699 963 person-years of follow-up, we identified 4232 deaths of all-cause, 1872 cancer deaths and 1021 cardiovascular deaths. The relation between weight change and all-cause mortality was reverse J-shaped. Multivariate hazard ratios (95% confidence interval) for weight loss of 5 kg or more versus weight change of less than 2.5 kg were 1.62 (1.45-1.81) in men and 1.76 (1.51-2.05) in women, whereas those for weight gain of 5 kg or more were 1.40 (1.22-1.59) in men and 1.25 (1.02-1.54) in women. These associations remained statistically significant even after the exclusion of deaths in the first 3 years of follow-up. The weight change-mortality association was pronounced in underweight persons or in nonsmoking men. The risk of cancer mortality increased in both men and women who lost weight by 5 kg or more. With regard to cardiovascular disease, mortality risk tended to increase with weight loss both in men and women, whereas its increase with weight gain was observed only in women. Conclusions: A large weight change, both loss and gain, was associated with an increased risk of mortality. Weight loss and gain may be predictors of early death in apparently healthy adult Japanese. International Journal of Obesity ( 2010) 34, 348-356; doi: 10.1038/ijo.2009.234; published online 17 November 2009

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据