期刊
INTERNATIONAL JOURNAL OF OBESITY
卷 33, 期 11, 页码 1235-1242出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ijo.2009.168
关键词
genetic linkage; body mass index; dizygotic twins; quantitative trait locus; heritability
资金
- European Commission under the program 'Quality of Life and Management of the Living Resources' of 5th Framework Programme [QLG2-CT-2002-01254]
- Genome-Wide Analyses of European Twin and Population Cohorts [EU/QLRT-2001-01254]
- NIH/NHLBI: STAMPEED [1-R01HL087679-01]
- Finnish Heart Association
- Sigrid Juselius Foundation
- Academy of Finland Centre of Excellence in Complex Disease Genetics
- Wellcome Trust
- BBSRC
- NHS NIHR Biomedical research centre Grant
- St Thomas' foundation hospitals trust
- Swedish Research Council [M-20051112]
- Swedish Foundation for Strategic Research
- NIAAA ( USA) [AA007535, AA013320, AA013326, AA014041, AA07728, AA10249, AA11998]
- NHMRC ( Australia) [941177, 951023, 950998, 981339, 241916, 941944]
- Netherlands Heart Foundation [86.083, 88.042, 90.313]
- Netherlands Organisation for Scientific Research [904-61090, SPI 56-464-14192, 480-04-004]
- Center Medical Systems Biology ( NWO Genomics)
- National Institute of Mental Health [R01 MH059160]
- Danish Medical Research Council
- The Danish Diabetes Foundation
- Danish Heart Foundation
- Novo Nordisk Foundation
Objective: To identify common loci and potential genetic variants affecting body mass index (BMI, kg m(-2)) in study populations originating from Europe. Design: We combined genome-wide linkage scans of six cohorts from Australia, Denmark, Finland, the Netherlands, Sweden and the United Kingdom with an similar to 10-cM microsatellite marker map. Variance components linkage analysis was carried out with age, sex and country of origin as covariates. Subjects: The GenomEUtwin consortium consists of twin cohorts from eight countries (Australia, Denmark, the Netherlands, Finland, Italy, Norway, Sweden and the United Kingdom) with a total data collection of more than 500 000 monozygotic and dizygotic (DZ) twin pairs. Variance due to early-life events and the environment is reduced within twin pairs, which makes DZ pairs highly valuable for linkage studies of complex traits. This study totaled 4401 European-originated twin families (10 535 individuals) from six countries (Australia, Denmark, the Netherlands, Finland, Sweden and the United Kingdom). Results: We found suggestive evidence for a quantitative trait locus on 3q29 and 7q36 in the combined sample of DZ twins (multipoint logarithm of odds score (MLOD) 2.6 and 2.4, respectively). Two individual cohorts showed strong evidence independently for three additional loci: 16q23 (MLOD = 3.7) and 2p24 (MLOD = 3.4) in the Dutch cohort and 20q13 (MLOD = 3.2) in the Finnish cohort. Conclusion: Linkage analysis of the combined data in this large twin cohort study provided evidence for suggestive linkage to BMI. In addition, two cohorts independently provided significant evidence of linkage to three new loci. The results of our study suggest a smaller environmental variance between DZ twins than full siblings, with a corresponding increase in heritability for BMI as well as an increase in linkage signal in well-replicated regions. The results are consistent with the possibility of locus heterogeneity for some genomic regions, and indicate a lack of major common quantitative trait locus variants affecting BMI in European populations. International Journal of Obesity (2009) 33, 1235-1242; doi:10.1038/ijo.2009.168; published online 1 September 2009
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据