期刊
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
卷 17, 期 12, 页码 1935-1942出版社
OXFORD UNIV PRESS
DOI: 10.1017/S1461145714000947
关键词
Anterior cingulate; cerebellar posterior lobe; major depressive disorder; medial frontal cortex; voxel-mirrored homotopic connectivity
资金
- Buddhist Tzu-Chi General Hospital
- Taipei Branch hospital project [TCRD-TPE-100-02]
- Cheng Hsin General Hospital
- National Yang Ming University [103F003C02]
- MR Centre, National Yang-Ming University, Taiwan
The issue of inter-hemispheric connectivity is an emerging new area in understanding the pathophysiology of depression. This study was designed to analyse the pattern of inter-hemispheric connectivity in patients with major depressive disorder (MDD). The resting-state functional magnetic resonance imaging (RFMRI) was acquired in all enrolled patients and controls. We used a method of voxel-mirrored homotopic connectivity (VMHC) to estimate the significant differences in inter-hemispheric connectivity between 44 patients with first-episode medication-naive MDD and 27 normal controls. The patients and controls were matched for age and gender. The patients with first-episode medication-naive MDD showed lower VMHC than normal controls in bilateral medial frontal cortex, anterior cingulate and cerebellar posterior lobe. The strength of inter-hemispheric connectivity VMHC value was negatively correlated with clinical severity of MDD. From the results, we suggested that decreased inter-hemispheric connectivity in the anterior sub-network of the default mode network and the cerebellar posterior lobe might represent an emerging finding in the pathophysiology for MDD.
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