期刊
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
卷 15, 期 9, 页码 1229-1239出版社
OXFORD UNIV PRESS
DOI: 10.1017/S1461145711001763
关键词
Children; COMT Val(158)Met; cortisol stress response; HPA axis; stressful life events
资金
- Deutsche Forschungsgemeinschaft [KI 537/20-1, 20-3, SFB 581, KFO 125, SFB TTR 58]
Dopamine and norepinephrine are key regulators of cognitive and affective processes. The enzyme catechol-O-methyltransferase (COMT) catabolizes catecholamines and the COMT Val(158)Met polymorphism has been linked to several neuropsychiatric variables. Additionally, stressful life events (SLEs) contribute substantially to affective processes. We used the stress-induced activation of the hypothalamic-pituitary-adrenal axis to investigate the effects of COMT and SLEs on the cortisol response in 119 healthy children (8-12 yr). Saliva cortisol was measured during and after the Trier Social Stress Test for Children. SLEs were assessed with a standardized interview with one of the children's parents. Linear regression analysis revealed a significant effect for COMT, with Met allele carriers showing a higher cortisol response (beta=0.300, p = 0.001). In turn, more SLEs lead to a less pronounced cortisol increase (beta = -0.192, p = 0.029) probably indicating increased resilience. Our results further underscore the essential and differential role of genetic variation and environmental factors on stress responsivity.
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