期刊
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
卷 12, 期 3, 页码 431-436出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1461145709000054
关键词
Dopamine; heroin; prelimbic; reinstatement; relapse
资金
- National Institute on Drug Abuse [DA10462, DA15369]
- NIH [C06 RR015455]
In brain regions that have been implicated in the reinstatement of drug-seeking, the prelimbic cortex has emerged as a critical regulator of relapse behaviours. Here, the effects of prelimbic cortex dopamine (DA) D(1) receptor antagonism on drug-seeking produced by heroin-paired cues, or by a single priming dose of heroin are examined. Rats lever-pressed daily for i.v. heroin discretely paired with a conditioned stimulus during 3-h sessions for a period of 2 wk, followed by extinction and reinstatement of drug-seeking by previously heroin-paired cues (tone+light) or heroin-priming injections (0.25 mg/kg) in the absence of heroin reinforcement. Intracranial infusion of the DA D(1) receptor antagonist, SCH 23390 (0.02-2.0 mu g/side), into the prelimbic cortex potently and dose dependently attenuated heroin-seeking in response to either cue presentations or a priming dose of heroin. These results suggest that DA D(1) receptors regulate prefrontal cortex pathways necessary for the reinstatement of heroin-seeking.
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