期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 9, 期 -, 页码 51-63出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S26592
关键词
drug delivery; endocytosis; exocytosis; cancer cell; macrophage; nanoparticle; toxicity
资金
- Ministry of Science, ICT and Future Planning [2012M3A9C6050125]
- National R&D Program for Cancer Control, Ministry for Health and Welfare [1220070]
- World Class University program - Ministry of Education, Science and Technology, Republic of Korea [R32-2008-000-10218-0]
- National Research Foundation of Korea
Engineered nanoparticles that can be injected into the human body hold tremendous potential to detect and treat complex diseases. Understanding of the endocytosis and exocytosis mechanisms of nanoparticles is essential for safe and efficient therapeutic application. In particular, exocytosis is of significance in the removal of nanoparticles with drugs and contrast agents from the body, while endocytosis is of great importance for the targeting of nanoparticles in disease sites. Here, we review the recent research on the endocytosis and exocytosis of functionalized nanoparticles based on various sizes, shapes, and surface chemistries. We believe that this review contributes to the design of safe nanoparticles that can efficiently enter and leave human cells and tissues.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据