期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 9, 期 -, 页码 1199-1213出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S57420
关键词
third-generation photosensitizer; nanoparticles; cancer; photodynamic therapy; drug delivery systems
资金
- Brazilian agencies: National Counsel of Technological and Scientific Development (CNPq)
- Brazilian agencies: National Counsel of Technological and Scientific Development (Braslia)
- Brazilian agencies: National Counsel of Technological and Scientific Development (Distrito Federal)
- Brazilian agencies: National Counsel of Technological and Scientific Development (Brazil)
- Agency for the Support and Evaluation of Graduate Education (CAPES)
- Agency for the Support and Evaluation of Graduate Education (Brasilia)
- Agency for the Support and Evaluation of Graduate Education (Distrito Federal)
- Agency for the Support and Evaluation of Graduate Education (Brazil)
- Funding Authority for Studies and Projects (FINEP, Rio de Janeiro, Rio de Janeiro, Brazil)
Photodynamic therapy is generally considered to be safer than conventional anticancer therapies, and it is effective against different kinds of cancer. However, its clinical application has been significantly limited by the hydrophobicity of photosensitizers. In this work, a system composed of the hydrophobic photosensitizer aluminum-phthalocyanine chloride (AlPc) associated with water dispersible poly(methyl vinyl ether-co-maleic anhydride) nanoparticles is described. AlPc was associated with nanoparticles produced by a method of solvent displacement. This system was analyzed for its physicochemical characteristics, and for its photodynamic activity in vitro in cancerous (murine mammary carcinoma cell lineage 4T1, and human mammary adenocarcinoma cells MCF-7) and noncancerous (murine fibroblast cell lineage NIH/3T3, and human mammary epithelial cell lineage MCF-10A) cell lines. Cell viability and the elicited mechanisms of cell death were evaluated after the application of photodynamic therapy. This system showed improved photophysical and photochemical properties in aqueous media in comparison to the free photosensitizer, and it was effective against cancerous cells in vitro.
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