期刊
MITOCHONDRION
卷 22, 期 -, 页码 60-65出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2015.03.003
关键词
Candida albicans; Mitochondria; Histidine kinase; Response regulator; Two-component; Virulence
Prokaryotes, eukaryotic microorganisms and plants utilize two-component signal transduction pathways to detect and respond to various environmental cues. These signaling cascades were acquired by eukaryotes via horizontal gene transfer events from ancestral bacteria. Recent exciting discoveries have identified twocomponent signaling systems in mitochondria and chloroplasts of several eulcaryotic microorganisms and plants, therefore providing important clues to the evolutionary transition of these signaling cascades from prokaryotes to eukaryotes. This review will focus on the role of two-component signal transduction pathways in fungal pathogenesis and also discuss key new discoveries of presence of proteins participating in these signaling pathways in mitochondrion. Before addressing these issues, I first briefly describe the magnitude and the economic impact of the healthcare problems caused by fungal pathogens. (C) 2015 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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