期刊
MITOCHONDRIAL DNA PART A
卷 27, 期 2, 页码 1045-1047出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/19401736.2014.926546
关键词
D-Loop; gastric cancer; mtDNA; SNPs
The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-Loop) of mitochondrial DNA (mtDNA) has been identified for their association with cancer risk in different types of cancers. We investigated the gastric cancer risk profile of D-Loop SNPs in a case-control study. The frequent alleles of nucleotides 73G/A, 235A/G, 309C/C insert, 324C/G, 16,362T/C and 16,519C/T were significantly associated with an increased risk for gastric cancer, whereas the frequent alleles of nucleotides 523-524AC/del were associated with resistance to gastric cancer. In conclusion, SNPs in the mtDNA D-Loop were found to be valuable markers for gastric cancer risk evaluation.
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