期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 8, 期 -, 页码 1621-1633出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S43589
关键词
ultrasound; targeted therapy; clinical application
资金
- National Natural Science Fund [81272160, 81071164, 81271584, 81000526]
- Zhejiang Provincial Natural Science Foundation [LY12H30003, LY12H31003, LQ12H30001, LY12H03001, LY12H18001, Y2110587, Y2090834]
- Beijing Natural Science Foundation [7112100]
- Scientific Research Joint Funds of Health Ministry and Zhejiang Province [WKJ2011-2-010]
- Wenzhou Bureau of Science and Technology [Y20090016, H20110008, Y20110034, S20100049, H20100017, Y20100029]
- Zhejiang Provincial Foundation for Health Department [2011ZDA017, 2012KYB126, 2012KYA134]
- Zhejiang Provincial Foundation for Education Department [Y201016664]
- Zhejiang Provincial Project of Key Scientific Group [2010R50042, 2012R10042-06]
- Major Scientific Project of Guangdong Province [2012A080201010]
Ultrasound is an important local stimulus for triggering drug release at the target tissue. Ultrasound-responsive drug delivery systems (URDDS) have become an important research focus in targeted therapy. URDDS include many different formulations, such as microbubbles, nanobubbles, nanodroplets, liposomes, emulsions, and micelles. Drugs that can be loaded into URDDS include small molecules, biomacromolecules, and inorganic substances. Fields of clinical application include anticancer therapy, treatment of ischemic myocardium, induction of an immune response, cartilage tissue engineering, transdermal drug delivery, treatment of Huntington's disease, thrombolysis, and disruption of the blood-brain barrier. This review focuses on recent advances in URDDS, and discusses their formulations, clinical application, and problems, as well as a perspective on their potential use in the future.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据