期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 7, 期 -, 页码 3099-3109出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S30934
关键词
fullerenol; nanomaterial; neurotoxicity; neuroprotection; hippocampal neuron
资金
- National Nature Science Foundation of China [31170965, 30630057]
- Chinese Ministry of Sciences [2012CB932502]
- Fundamental Research Funds for the Central Universities [WK2070000002, 2070000004, 2070000008]
Background: Recent studies have shown that the biological actions and toxicity of the water-soluble compound, polyhydroxyfullerene (fullerenol), are related to the concentrations present at a particular site of action. This study investigated the effects of different concentrations of fullerenol on cultured rat hippocampal neurons. Methods and results: Fullerenol at low concentrations significantly enhanced hippocampal neuron viability as tested by MTT assay and Hoechst 33342/propidium iodide double stain detection. At high concentrations, fullerenol induced apoptosis confirmed by Comet assay and assessment of caspase proteins. Conclusion: These findings suggest that fullerenol promotes cell death and protects against cell damage, depending on the concentration present. The concentration-dependent effects of fullerenol were mainly due to its influence on the reduction-oxidation pathway.
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