期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 7, 期 -, 页码 2557-2571出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S29145
关键词
cross-linked micelle; cisplatin; ovarian cancer; block ionomer complex; drug delivery
资金
- USA National Institutes of Health [CA116590]
- NIH [1P20RR021937]
- USA NSF [0411164]
- NATIONAL CANCER INSTITUTE [R01CA116590] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR021937] Funding Source: NIH RePORTER
Polymer micelles with cross-linked ionic cores are shown here to improve the therapeutic performance of the platinum-containing anticancer compound cisplatin. Biodistribution, antitumor efficacy, and toxicity of cisplatin-loaded core cross-linked micelles of poly(ethylene glycol)-b-poly(methacrylic acid) were evaluated in a mouse ovarian cancer xenograft model. Cisplatin-loaded micelles demonstrated prolonged blood circulation, increased tumor accumulation, and reduced renal exposure. Improved antitumor response relative to free drug was seen in a mouse model. Toxicity studies with cisplatin-loaded micelles indicate a significantly improved safety profile and lack of renal abnormalities typical of free cisplatin treatment. Overall, the study supports the fundamental possibility of improving the potential of platinum therapy using polymer micelle-based drug delivery.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据