期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 6, 期 -, 页码 649-657出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S17242
关键词
nanoemulsion; 3,5-dihydroxy-4-isopropylstilbene; DHPS; pseudo-ternary phase diagram
We have reported a novel procedure to prepare 3,5-dihydroxy-4-isopropylstilbene (DHPS) nanoemulsion, using a low-energy emulsification method. Based on the phase diagram, the optimum prescription of nanoemulsion preparation was screened. With polyoxyethylenated castor oil (EL-40) as the surfactant, ethanol as the co-surfactant, and isopropyl myristate (IPM) as the oil phase, the DHPS nanoemulsion was obtained with a transparent appearance, little viscosity, and spherically uniform distribution verified by transmission electron microscopy and laser scattering analyzer. The nanoemulsion was also determined by FT-Raman spectroscopy. The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties. The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 mu g . cm(-2) to 273.15 mu g . cm(-2)) and could become a favorable new dosage form for DHPS.
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