期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 19, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/ijms19092569
关键词
cytokines; interleukins; inflammation; energy and metabolic homeostasis; thermogenesis; brown and beige adipose tissue
资金
- European Community [245009]
- Ministerio de Economia, Industria y Competitividad, Gobierno de Espana [BFU2007-62683]
- Conselleria de Cultura, Educacion e Ordenacion Universitaria, Xunta de Galicia [GPC2014/030]
- CIBER de Fisiopatologia de la Obesidad y Nutricion [CB06/03]
- CIBER de Fisiopatologia de la Obesidad y Nutricion is an initiative of ISCIII
Obesity rates and the burden of metabolic associated diseases are escalating worldwide Energy burning brown and inducible beige adipocytes in human adipose tissues (ATs) have attracted considerable attention due to their therapeutic potential to counteract the deleterious metabolic effects of nutritional overload and overweight. Recent research has highlighted the relevance of resident and recruited ATs immune cell populations and their signalling mediators, cytokines, as modulators of the thermogenic activity of brown and beige ATs. In this review, we first provide an overview of the developmental, cellular and functional heterogeneity of the AT organ, as well as reported molecular switches of its heat-producing machinery. We also discuss the key contribution of various interleukins signalling pathways to energy and metabolic homeostasis and their roles in the biogenesis and function of brown and beige adipocytes. Besides local actions, attention is also drawn to their influence in the central nervous system (CNS) networks governing energy expenditure.
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