期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 19, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/ijms19082424
关键词
gastric cancer; diffuse gastric cancer; hereditary diffuse gastric cancer; contributing factors
资金
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan [221S0002, 16H06279, 15H02657, 16H05191]
- Japan Society for the Promotion of Science (Core-to-Core Program)
- National Institutes of Health [DK62813]
- Japanese Government (MEXT)
Gastric cancer is the third leading cause of cancer-related deaths and ranks as the fifth most common cancer worldwide. Incidence and mortality differ depending on the geographical region and gastric cancer ranks first in East Asian countries. Although genetic factors, gastric environment, and Helicobacter pylori infection have been associated with the pathogenicity and development of intestinal-type gastric cancer that follows the Correa's cascade, the pathogenicity of diffuse-type gastric cancer remains mostly unknown and undefined. However, genetic abnormalities in the cell adherence factors, such as E-cadherin and cellular activities that cause impaired cell integrity and physiology, have been documented as contributing factors. In recent years, H. pylori infection has been also associated with the development of diffuse-type gastric cancer. Therefore, in this report, we discuss the host factors as well as the bacterial factors that have been reported as associated factors contributing to the development of diffuse-type gastric cancer.
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