期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 15, 期 5, 页码 8360-8371出版社
MDPI AG
DOI: 10.3390/ijms15058360
关键词
Plectranthus barbatus; antiprotozoal; abietane-type diterpenoids; Plasmodium; Leishmania; Trypanosoma; cytotoxicity
资金
- NSTIP strategic technologies programs in the Kingdom of Saudi Arabia [10-MED1288-02]
Chromatographic separation of the n-hexane extract of the aerial part of Plectranthus barbatus led to the isolation of five abietane-type diterpenes: dehydroabietane (1); 5,6-didehydro-7-hydroxy-taxodone (2); taxodione (3); 20-deoxocarnosol (4) and 6 alpha, 11,12,-trihydroxy-7 beta, 20-epoxy-8,11,13-abietatriene (5). The structures were determined using spectroscopic methods including one-and two-dimensional NMR methods. Compounds (1)-(3) and (5) are isolated here for the first time from the genus Plectranthus. The isolated abietane-type diterpenes tested in vitro for their antiprotozoal activity against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi and free trypomastigotes of T. brucei. Cytotoxicity was determined against fibroblast cell line MRC-5. Compound (2) 5,6-didehydro-7-hydroxy-taxodone showed remarkable activity with acceptable selectivity against P. falciparum (IC50 9.2 mu M, SI 10.4) and T. brucei (IC50 1.9 mu M, SI 50.5). Compounds (3)-(5) exhibited non-specific antiprotozoal activity due to high cytotoxicity. Compound (1) dehydroabietane showed no antiprotozoal potential.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据