4.7 Review

From Plasminogen to Plasmin: Role of Plasminogen Receptors in Human Cancer

期刊

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 15, 期 11, 页码 21229-21252

出版社

MDPI AG
DOI: 10.3390/ijms151121229

关键词

actin; annexin 2; cytokeratin-8; enolase-1; plasmin; plasminogen; plasminogen receptor

资金

  1. Excellence Cluster Cardiopulmonary System (ECCPS)
  2. German Center for Pulmonary Research (DZL: Deutsches Zentrum fur Lungenforschung)
  3. [SFB/TR84]

向作者/读者索取更多资源

Cell surface-associated proteolysis mediated by plasmin (PLA) is an essential feature of wound healing, angiogenesis and cell invasion, processes that are dysregulated in cancer development, progression and systemic spread. The generation of PLA, initiated by the binding of its precursor plasminogen (PLG) to the cell surface, is regulated by an array of activators, inhibitors and receptors. In this review, we will highlight the importance of the best-characterized components of the PLG/PLA cascade in the pathogenesis of cancer focusing on the role of the cell surface-PLG receptors (PLG-R). PLG-R overexpression has been associated with poor prognosis of cancer patients and resistance to chemotherapy. We will also discuss recent findings on the molecular mechanisms regulating cell surface expression and distribution of PLG-R.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据