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Ghrelin is neuroprotective in Parkinson's disease: molecular mechanisms of metabolic neuroprotection
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Growth hormone secretagogue receptor (GHS-R1a) knockout mice exhibit improved spatial memory and deficits in contextual memory
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The truncated ghrelin receptor polypeptide (GHS-R1b) is localized in the endoplasmic reticulum where it forms heterodimers with ghrelin receptors (GHS-R1a) to attenuate their cell surface expression
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Inactivation of the Constitutively Active Ghrelin Receptor Attenuates Limbic Seizure Activity in Rodents
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Hypothalamic mTOR Signaling Mediates the Orexigenic Action of Ghrelin
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Ghrelin inhibits AGEs-induced apoptosis in human endothelial cells involving ERK1/2 and PI3K/Akt pathways
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Mutually Opposite Signal Modulation by Hypothalamic Heterodimerization of Ghrelin and Melanocortin-3 Receptors
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Identification and Functional Analysis of Novel Human Growth Hormone Secretagogue Receptor (GHSR) Gene Mutations in Japanese Subjects with Short Stature
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Signaling through the ghrelin receptor modulates hippocampal function and meal anticipation in mice
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Mutational analysis of predicted extracellular domains of human growth hormone secretagogue receptor 1a
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Unsaturated fatty acids prevent desensitization of the human growth hormone secretagogue receptor by blocking its internalization
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Activation of the Ghrelin Receptor is Described by a Privileged Collective Motion: A Model for Constitutive and Agonist-induced Activation of a Sub-class A G-Protein Coupled Receptor (GPCR)
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Altered myocardial expression of ghrelin and its receptor (GHSR-1a) in patients with severe heart failure
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In Vivo Characterization of High Basal Signaling from the Ghrelin Receptor
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UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals
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NATURE (2008)
Importance of constitutive activity and arrestin independent mechanisms for intracellular trafficking of the ghrelin receptor
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MOLECULAR ENDOCRINOLOGY (2007)
Adenosine is not a direct GHSR agonist - artificial cross-talk between GHSR and adenosine receptor pathways
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Over-expression of the truncated ghrelin receptor polypeptide attenuates the constitutive activation of phosphatidylinositol-specific phospholipase C by ghrelin receptors but has no effect on ghrelin-stimulated extracellular signal-regulated kinase 1/2 activity
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INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)
Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers
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MOLECULAR ENDOCRINOLOGY (2006)
Characterization of ghrelin receptor activity in a rat pituitary cell line RC-4B/C
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Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature
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Ghrelin receptor inverse agonists: Identification of an active peptide core and its interaction epitopes on the receptor
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MOLECULAR PHARMACOLOGY (2006)
Construction of human ghrelin receptor (hGHS-R1a) model using a fragmental prediction approach and validation through docking analysis
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JOURNAL OF MEDICINAL CHEMISTRY (2006)
Biological, physiological, and pharmacological aspects of ghrelin
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Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study
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GUT (2005)
Developments in ghrelin biology and potential clinical relevance
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TRENDS IN ENDOCRINOLOGY AND METABOLISM (2005)
Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle
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Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Desensitization and endocytosis mechanisms of ghrelin-activated growth hormone secretagogue receptor 1a
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ENDOCRINOLOGY (2004)
Effect of GHRH and GHRP-2 treatment in vitro on GH secretion and levels of GH, pituitary transcription factor-1, GHRH-receptor, GH-secretagogue-receptor and somatostatin receptor mRNAs in ovine pituitary cells
M Yan et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2004)
The mitogenic and antiapoptotic actions of ghrelin in 3T3-L1 adipocytes
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MOLECULAR ENDOCRINOLOGY (2004)
Ghrelin enhances the growth of cultured human adrenal zona glomerulosa cells by exerting MAPK-mediated proliferogenic and antiapoptotic effects
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Common structural basis for constitutive activity of the ghrelin receptor family
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Homologous and heterologous regulation of pituitary receptors for ghrelin and growth hormone-releasing hormone
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Ghrelin receptor gene: Identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal stature
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Agonist-specific coupling of growth hormone secretagogue receptor type 1a to different intracellular signaling systems - Role of adenosine
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Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus Ca2+ signalling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin
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High constitutive signaling of the ghrelin receptor - Identification of a potent inverse agonist
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Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT
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Ghrelin modulates the downstream molecules of insulin signaling in hepatoma cells
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Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion
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Thyroid hormones regulate pituitary growth hormone secretagogue receptor gene expression
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Hexosamine-induced fibronectin protein synthesis in mesangial cells is associated with increases in cAMP responsive element binding (CREB) phosphorylation and nuclear CREB - The involvement of protein kinases A and C
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Hormonal regulation of the human ghrelin receptor gene transcription
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
In vivo and in vitro effects of ghrelin/motilin-related peptide on growth hormone secretion in the rat
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Developmentally and regionally regulated expression of growth hormone secretagogue receptor mRNA in rat brain and pituitary gland
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