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Making the Bend: DNA Tertiary Structure and Protein-DNA Interactions

期刊

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 15, 期 7, 页码 12335-12363

出版社

MDPI
DOI: 10.3390/ijms150712335

关键词

DNA structure; DNA structure recognition; protein-DNA interactions

资金

  1. German Research Foundation (DFG)
  2. Technische Universitat Munchen
  3. excellence cluster CIPSM
  4. Fond der chemischen Industrie

向作者/读者索取更多资源

DNA structure functions as an overlapping code to the DNA sequence. Rapid progress in understanding the role of DNA structure in gene regulation, DNA damage recognition and genome stability has been made. The three dimensional structure of both proteins and DNA plays a crucial role for their specific interaction, and proteins can recognise the chemical signature of DNA sequence (base readout) as well as the intrinsic DNA structure (shape recognition). These recognition mechanisms do not exist in isolation but, depending on the individual interaction partners, are combined to various extents. Driving force for the interaction between protein and DNA remain the unique thermodynamics of each individual DNA-protein pair. In this review we focus on the structures and conformations adopted by DNA, both influenced by and influencing the specific interaction with the corresponding protein binding partner, as well as their underlying thermodynamics.

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