期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 15, 期 6, 页码 9331-9342出版社
MDPI
DOI: 10.3390/ijms15069331
关键词
pre-mRNA splicing; RNase R; circular RNA; multiexon skipping
资金
- JSPS (Japan Society for the Promotion of Science) [24700974]
- Intramural Research Grant for Neurological and Psychiatric Disorders of NCNP (National center of Neurology and Psychiatry) [25-5]
- JSPS
- Grants-in-Aid for Scientific Research [26670167, 24700974] Funding Source: KAKEN
During pre-mRNA splicing, exons in the primary transcript are precisely connected to generate an mRNA. Intron lariat RNAs are formed as by-products of this process. In addition, some exonic circular RNAs (circRNAs) may also result from exon skipping as by-products. Lariat RNAs and circRNAs are both RNase R resistant RNAs. RNase R is a strong 3' to 5' exoribonuclease, which efficiently degrades linear RNAs, such as mRNAs and rRNAs; therefore, the circular parts of lariat RNAs and the circRNAs can be segregated from eukaryotic total RNAs by their RNase R resistance. Thus, RNase R resistant RNAs could provide unexplored splicing information not available from mRNAs. Analyses of these RNAs identified repeating splicing phenomena, such as re-splicing of mature mRNAs and nested splicing. Moreover, circRNA might function as microRNA sponges. There is an enormous variety of endogenous circRNAs, which are generally synthesized in cells and tissues.
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