期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 16, 期 1, 页码 321-349出版社
MDPI
DOI: 10.3390/ijms16010321
关键词
tRNA; protein translation; antibiotics; stringent response; biogenesis
资金
- National Science Foundation [1158488]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1158488] Funding Source: National Science Foundation
Transfer RNAs (tRNAs) are central players in the protein translation machinery and as such are prominent targets for a large number of natural and synthetic antibiotics. This review focuses on the role of tRNAs in bacterial antibiosis. We will discuss examples of antibiotics that target multiple stages in tRNA biology from tRNA biogenesis and modification, mature tRNAs, aminoacylation of tRNA as well as prevention of proper tRNA function by small molecules binding to the ribosome. Finally, the role of deacylated tRNAs in the bacterial stringent response mechanism that can lead to bacteria displaying antibiotic persistence phenotypes will be discussed.
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