期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 15, 期 11, 页码 20045-20053出版社
MDPI
DOI: 10.3390/ijms151120045
关键词
sponge; Scalarispongia; sesterterpenoid; scalarane; cytotoxicity
资金
- Korea Institute of Ocean Science and Technology
- Ministry of Oceans and Fisheries of Korea
Eight scalarane sesterterpenoids, including four new compounds, were isolated from the marine sponge Scalarispongia sp. The structures of the new compounds were elucidated by 2D-NMR and HRMS analyses. All of the isolated compounds, with the exception of 16-O-deacetyl-12,16-epi-scalarolbutanolide, showed significant in vitro cytotoxicity (GI50 values down to 5.2 mu M) against six human cancer cell lines.
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