期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 15, 期 3, 页码 4977-4993出版社
MDPI
DOI: 10.3390/ijms15034977
关键词
resveratrol; non-Hodgkin lymphoma; apoptosis
资金
- Italian Ministry of Health, Bando Progetti di Ricerca Giovani Ricercatori-Ricerca Finalizzata [GR-2010-2320280]
Lymphoma and leukemia represent a serious threat to human health and life expectancy. Resveratrol is, among the natural-derived chemopreventive molecules, one of the most effective and better studied. In this paper the main mechanisms of cell death triggered by- or linked to- resveratrol are reviewed and discussed. The main focus is on lymphoma and leukemia experimental models where resveratrol has been tested and investigated at the cellular, molecular or physiological levels. The most relevant in vivo challenges involving resveratrol are also reported and analyzed in order to define the key features of this polyphenol and the potential for the treatment of hematologic tumors.
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