期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 15, 期 2, 页码 145-156出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557515666150101100509
关键词
Biological activity; piperine; structural modifications; structure-activity relationship
资金
- Special Funds of Central Colleges Basic Scientific Research Operating Expenses, Northwest AF University [YQ2013008]
Piperine is a simple alkaloid isolated from the seeds of Piper nigrum. Piperine and its derivatives exhibited a wide range of biological properties such as antitumor activity, antioxidant activity, anti-inflammatory activity, antimycobacterial activity, insecticidal activity, etc. Although five excellent reviews have recently been described by Srinivasan in 2007, Mao in 2011, Butt in 2013, and Meghwal in 2013, respectively, their topics were mainly focused on the biological effects. Therefore, in the present review, the progress in the structural modifications on the aliphatic chain and the amide moiety of piperine was reported. Meanwhile, the biological activities and structure-activity relationship of piperine and its derivatives were also described.
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