期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 15, 期 4, 页码 6717-6724出版社
MDPI
DOI: 10.3390/ijms15046717
关键词
cell-free protein synthesis system; in vitro selection; in vitro virus; protein-protein interaction
资金
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan [4201, 23134510]
- Shiseido Co., Ltd.
- Grants-in-Aid for Scientific Research [4201, 23134510] Funding Source: KAKEN
We have developed a simple in vitro virus (IVV) selection system based on cell-free co-translation, using a highly stable and efficient mRNA display method. The IVV system is applicable to the high-throughput and comprehensive analysis of proteins and protein-ligand interactions. Huge amounts of genomic sequence data have been generated over the last decade. The accumulated genetic alterations and the interactome networks identified within cells represent a universal feature of a disease, and knowledge of these aspects can help to determine the optimal therapy for the disease. The concept of the integrome has been developed as a means of integrating large amounts of data. We have developed an interactome analysis method aimed at providing individually-targeted health care. We also consider future prospects for this system.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据