期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 15, 期 5, 页码 8443-8457出版社
MDPI
DOI: 10.3390/ijms15058443
关键词
palmultang; inducible nitric oxide synthase; heme oxygenase-1; nuclear factor-kappaB; mitogen-activated protein kinase
资金
- Ministry of Education, Science and Technology (MEST), Korea [K14050]
- National Research Council of Science & Technology (NST), Republic of Korea [K14050] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Palmultang (PM) is an herbal decoction that has been used to treat anorexia, anemia, general prostration, and weakness due to chronic illness since medieval times in Korea, China, and Japan. The present study focused on the inhibitory effects of PM on the production of inflammatory factors and on the activation of mechanisms in murine macrophages. PM suppressed the expression of nitric oxide (NO), inflammatory cytokines and inflammatory proteins by inhibiting nuclear factor (NF)-kappa B and mitogen-activated protein kinase (MAPK) signaling pathways and by inducing heme oxygenase (HO)-1 expression. Collectively, our results explain the anti-inflammatory effect and inhibitory mechanism of PM in macrophages stimulated with lipopolysaccharide (LPS).
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