期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 15, 期 4, 页码 5388-5409出版社
MDPI
DOI: 10.3390/ijms15045388
关键词
ATM kinase; cancer development and therapy; DNA damage response (DDR); apoptosis; receptor tyrosine kinase; oxidative stress; hypoxia and angiogenesis; death receptors; stem cells
资金
- AIRC [IG10590]
- PRIN [2010M4NEFY_005]
- Giovani Ricercatori-Ministero della Salute [GR10.120]
Ataxia-telangiectasia mutated (ATM) kinase is a one of the main guardian of genome stability and plays a central role in the DNA damage response (DDR). The deregulation of these pathways is strongly linked to cancer initiation and progression as well as to the development of therapeutic approaches. These observations, along with reports that identify ATM loss of function as an event that may promote tumor initiation and progression, point to ATM as a bona fide tumor suppressor. The identification of ATM as a positive modulator of several signalling networks that sustain tumorigenesis, including oxidative stress, hypoxia, receptor tyrosine kinase and AKT serine-threonine kinase activation, raise the question of whether ATM function in cancer may be more complex. This review aims to give a complete overview on the work of several labs that links ATM to the control of the balance between cell survival, proliferation and death in cancer.
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