期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 14, 期 1, 页码 1854-1869出版社
MDPI AG
DOI: 10.3390/ijms14011854
关键词
quaternized CS; antimicrobial activity; mechanism; application; orthopedics
资金
- National Natural Science Foundation of China [31271015]
- Shanghai Municipal Education Commission
- Shanghai Municipal Education Commission [J50206]
- Key Laboratory of Inorganic Coating Materials
- Chinese Academy of Science
- Applied Basic Research Programs of Changzhou [CJ20112001]
Chitosan (CS) is a linear polysaccharide with good biodegradability, biocompatibility and antimicrobial activity, which makes it potentially useful for biomedical applications, including an antimicrobial agent either alone or blended with other polymers. However, the poor solubility of CS in most solvents at neutral or high pH substantially limits its use. Quaternary ammonium CS, which was prepared by introducing a quaternary ammonium group on a dissociative hydroxyl group or amino group of the CS, exhibited improved water solubility and stronger antibacterial activity relative to CS over an entire range of pH values; thus, this quaternary modification increases the potential biomedical applications of CS in the field of anti-infection. This review discusses the current findings on the antimicrobial properties of quaternized CS synthesized using different methods and the mechanisms of its antimicrobial actions. The potential antimicrobial applications in the orthopedic field and perspectives regarding future studies in this field are also considered.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据