期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 14, 期 12, 页码 24706-24725出版社
MDPI
DOI: 10.3390/ijms141224706
关键词
cancer stem cells; multidrug resistance; neuroblastoma; hepatoblastoma
资金
- Associazione Italiana per la Ricerca sul Cancro (AIRC, Milan, Italy) [MFAG 12936, IG 1506]
- [5 x 1000 AIRC]
Chemotherapy is one of the major modalities in treating cancers. However, its effectiveness is limited by the acquisition of multidrug resistance (MDR). Several mechanisms could explain the up-regulation of MDR genes/proteins in cancer after chemotherapy. It is known that cancer stem cells (CSCs) play a role as master regulators. Therefore, understanding the mechanisms that regulate some traits of CSCs may help design efficient strategies to overcome chemoresistance. Different CSC phenotypes have been identified, including those found in some pediatric malignancies. As solid tumors in children significantly differ from those observed in adults, this review aims at providing an overview of the mechanistic relationship between MDR and CSCs in common solid tumors, and, in particular, focuses on clinical as well as experimental evidence of the relations between CSCs and MDR in neuroblastoma and hepatoblastoma. Finally, some novel approaches, such as concomitant targeting of multiple key transcription factors governing the stemness of CSCs, as well as nanoparticle-based approaches will also be briefly addressed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据