期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 14, 期 8, 页码 17085-17110出版社
MDPI
DOI: 10.3390/ijms140817085
关键词
small non-coding RNAs; long non-coding RNAs; cancer
资金
- Kimmel Award
The discovery of the biological relevance of non-coding RNA (ncRNAs) molecules represents one of the most significant advances in contemporary molecular biology. Expression profiling of human tumors, based on the expression of miRNAs and other short or long ncRNAs, has identified signatures associated with diagnosis, staging, progression, prognosis, and response to treatment. In this review we will discuss the recent remarkable advancement in the understanding the biological functions of human ncRNAs in cancer, the mechanisms of expression and the therapeutic potential.
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