期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 14, 期 8, 页码 17221-17237出版社
MDPI
DOI: 10.3390/ijms140817221
关键词
periodontal pathogens; environmental stimuli; biofilm EPS; virulence factors
资金
- Academy of Finland
- Paulo Foundation
- Ella and Georg Ehrnrooth Foundation
- Turku University Foundation
- Finnish Dental Society Apollonia
Periodontitis is a common inflammatory disease affecting the tooth-supporting structures. It is initiated by bacteria growing as a biofilm at the gingival margin, and communication of the biofilms differs in health and disease. The bacterial composition of periodontitis-associated biofilms has been well documented and is under continual investigation. However, the roles of several host response and inflammation driven environmental stimuli on biofilm formation is not well understood. This review article addresses the effects of environmental factors such as pH, temperature, cytokines, hormones, and oxidative stress on periodontal biofilm formation and bacterial virulence.
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