期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 14, 期 9, 页码 17279-17303出版社
MDPI
DOI: 10.3390/ijms140917279
关键词
chemoprevention; colorectal cancer; NSAIDs; aspirin; natural compounds; COX-2; NF-B; survivin; IGF-1
The step-wise development of colorectal neoplasia from adenoma to carcinoma suggests that specific interventions could delay or prevent the development of invasive cancer. Several key factors involved in colorectal cancer pathogenesis have already been identified including cyclooxygenase 2 (COX-2), nuclear factor kappa B (NF-B), survivin and insulin-like growth factor-I (IGF-I). Clinical trials of COX-2 inhibitors have provided the proof of principle that inhibition of this enzyme can prevent the formation of colonic adenomas and potentially carcinomas, however concerns regarding the potential toxicity of these drugs have limited their use as a chemopreventative strategy. Curcumin, resveratrol and quercetin are chemopreventive agents that are able to suppress multiple signaling pathways involved in carcinogenesis and hence are attractive candidates for further research.
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