期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 14, 期 10, 页码 20890-20912出版社
MDPI AG
DOI: 10.3390/ijms141020890
关键词
glycoproteins; boronic acid; separation; sensing
资金
- National Natural Science Foundation of China [21205003, 21305004]
- Joint Fund for Fostering Talents of National Natural Science Foundation of China and Henan province [U1304205]
Glycoproteins influence a broad spectrum of biological processes including cell-cell interaction, host-pathogen interaction, or protection of proteins against proteolytic degradation. The analysis of their glyco-structures and concentration levels are increasingly important in diagnosis and proteomics. Boronic acids can covalently react with cis-diols in the oligosaccharide chains of glycoproteins to form five- or six-membered cyclic esters. Based on this interaction, boronic acid-based ligands and materials have attracted much attention in both chemistry and biology as the recognition motif for enrichment and chemo/biosensing of glycoproteins in recent years. In this work, we reviewed the progress in the separation, immobilization and detection of glycoproteins with boronic acid-functionalized materials and addressed its application in sensing.
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