期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 14, 期 4, 页码 7829-7852出版社
MDPI
DOI: 10.3390/ijms14047829
关键词
Intersectin; endocytosis; cell signaling; Ras; PI3KC2 beta; Down Syndrome; Alzheimer Disease; cancer; neuroblastoma; glioblastoma
资金
- National Institutes of Health
- St. Baldrick's Foundation
- Foundation Jerome Lejeune
- Chicago Biomedical Consortium
- Chicago Community Trust
Intersectins (ITSNs) represent a family of multi-domain adaptor proteins that regulate endocytosis and cell signaling. ITSN genes are highly conserved and present in all metazoan genomes examined thus far. Lower eukaryotes have only one ITSN gene, whereas higher eukaryotes have two ITSN genes. ITSN was first identified as an endocytic scaffold protein, and numerous studies reveal a conserved role for ITSN in endocytosis. Subsequently, ITSNs were found to regulate multiple signaling pathways including receptor tyrosine kinases (RTKs), GTPases, and phosphatidylinositol 3-kinase Class 2beta (PI3KC2 beta). ITSN has also been implicated in diseases such as Down Syndrome (DS), Alzheimer Disease (AD), and other neurodegenerative disorders. This review summarizes the evolutionary conservation of ITSN, the latest research on the role of ITSN in endocytosis, the emerging roles of ITSN in regulating cell signaling pathways, and the involvement of ITSN in human diseases such as DS, AD, and cancer.
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