期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 14, 期 8, 页码 15233-15259出版社
MDPI
DOI: 10.3390/ijms140815233
关键词
plant virus; DNA virus; geminivirus; pararetrovirus; silencing; siRNA; RNA-directed DNA methylation; cytosine methylation; silencing evasion; suppressor protein
资金
- Swiss National Science Foundation [31003A_143882/1]
- Indo-Swiss Collaboration in Biotechnology
- European Collaboration in Science and Technology (COST) [C09.0176, FA0806]
- Swiss National Science Foundation (SNF) [31003A_143882] Funding Source: Swiss National Science Foundation (SNF)
Plants infected with DNA viruses produce massive quantities of virus-derived, 24-nucleotide short interfering RNAs (siRNAs), which can potentially direct viral DNA methylation and transcriptional silencing. However, growing evidence indicates that the circular double-stranded DNA accumulating in the nucleus for Pol II-mediated transcription of viral genes is not methylated. Hence, DNA viruses most likely evade or suppress RNA-directed DNA methylation. This review describes the specialized mechanisms of replication and silencing evasion evolved by geminiviruses and pararetoviruses, which rescue viral DNA from repressive methylation and interfere with transcriptional and post-transcriptional silencing of viral genes.
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