期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 16, 期 1, 页码 40-54出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557515666151016125948
关键词
Activity; application; aryloxyaminopropanol derivatives; beta-blockers; structure
It has been over half a century since propranolol, the first beta-blocker, was developed for medical treatment. Since that time a large number of compounds from this group have been synthesised and many are now in clinical use. The structure, function, pharmacokinetics, and mechanism of beta-blockers have been established. The possibilities for their use in treating different conditions continue to evolve. Since the discovery of later generation beta-blockers, such as carvedilol and nebivolol, the search for new compounds continues, and may include known substances with beta-blocking properties which could extend their therapeutic potential.
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