期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 14, 期 4, 页码 6649-6673出版社
MDPI
DOI: 10.3390/ijms14046649
关键词
diacylglycerol kinase; DGK; signal transduction; T cells; iNKT cells; anergy; tumor immunity
资金
- Abramson Family Cancer Research Institute
- National Institutes of Health
Diacylglycerol kinases (DGKs) are a diverse family of enzymes that catalyze the conversion of diacylglycerol (DAG), a crucial second messenger of receptor-mediated signaling, to phosphatidic acid (PA). Both DAG and PA are bioactive molecules that regulate a wide set of intracellular signaling proteins involved in innate and adaptive immunity. Clear evidence points to a critical role for DGKs in modulating T cell activation, function, and development. More recently, studies have elucidated factors that control DGK function, suggesting an added complexity to how DGKs act during signaling. This review summarizes the available knowledge of the function and regulation of DGK isoforms in signal transduction with a particular focus on T lymphocytes.
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